SKIN SQUAMOUS CELL: Recurrent: Intratumoral XRT: Alpha DaRT224-03

Study snapshot

Patients with recurrent cutaneous SCC histologically confirmed who have failed at least first line standard of care therapy who are not indicated for surgery and standard radiation therapy, or non alpha radiation brachytherapy technologies, and for whom no curative systemic treatment is available
Histopathological confirmation following previous treatment
Measurable disease
One single lesion
Tumor size </= 7cm
Targeted lesion must be technically amenable for complete coverage (including margins) by the DaRT seeds.Targets will be deemed technically amenable for complete coverage if there are entry and exit vectors for placement that are not hindered by bone or major vessels or other vital organs (eg. eye)
ECOG PS 0-2
No distant or nodal metastatic disease
No T4 disease or perineural spread
No previously untreated disease indicated for surgery or radiation
No mucosal, vulvar, anal, or penile SCC
No systemic immunosuppresive therapy
No keratoacanthoma histology
No clinically significant cardiovascular disease